Pharmacogenetic screening
نویسندگان
چکیده
منابع مشابه
PharmGED: Pharmacogenetic Effect Database
Prediction and elucidation of pharmacogenetic effects is important for facilitating the development of personalized medicines. Knowledge of polymorphism-induced and other types of drug-response variations is needed for facilitating such studies. Although databases of pharmacogenetic knowledge, polymorphism and toxicogenomic information have appeared, some of the relevant data are provided in se...
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CMAJ © 2009 Canadian Medical Association or its licensors 1 A35-year-old man of Chinese ethnicity presented to the emergency department with fever, rash, mouth pain and visual impairment after two weeks of therapy with allopurinol. On examination, the patient had a generalized maculopapular rash, orolabial ulceration (Figure 1), keratoconjunctivitis with pseudomembrane formation (Figure 2) and ...
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Pharmacogenetics (PGx) - the study of DNA variation in the human genome and the way this impacts the efficacy and safety of medicines - is becoming an increasingly important research tool as physicians, patients, regulatory authorities and payers look for innovative ways to improve the risk:benefit ratio of medicines. While scientific knowledge about PGx is rapidly increasing, implementation of...
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PURPOSE Despite the extensive clinical experience with docetaxel, unpredictable interindividual variability in efficacy and toxicity remain important limitations associated with the use of this anticancer drug. Large interindividual pharmacokinetic variability has been associated with variation in toxicity profiles. Genetic polymorphisms in drug-metabolizing enzymes and drug transporters could ...
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Abacavir hypersensitivity reaction (ABC-HSR) is associated with the presence of HLA-B*5701 allele. Alternative tests for ABC-HSR associated allele determination are needed where sequence-based HLA typing is not available, particularly in resource-limited settings or developing countries. This study focused on the development and evaluation of two HLA-B*5701 tagging SNPs (single nucleotide polym...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2010
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.110-2062